[ti:Study: Electrical Medical Device Helps Improve Muscle Strength]
[by:www.21voa.com]
[00:00.00]更多听力请访问21VOA.COM
[00:00.04]Researchers recently reported
[00:02.76]new evidence from a study of a medical device
[00:07.00]placed inside the body,
[00:09.24]a spine-stimulating implant.
[00:13.56]Three people with a muscle-destroying disease
[00:17.32]got a little stronger after using the implant.
[00:23.08]They were able to stand and walk more easily
[00:27.56]because of electrical stimulation to their spinal cord.
[00:34.80]Marco Capogrosso is an assistant professor
[00:39.28]at the University of Pittsburg,
[00:41.44]or Pitt, who led the research.
[00:45.64]"These people were definitely
[00:47.96]not expecting an improvement," he said.
[00:52.60]Capogrosso said, "They were getting better and better,"
[00:57.16]over the study that lasted one month.
[01:01.32]The implant was able to return
[01:04.12]some muscle function, at least temporarily.
[01:09.52]The implant was already being tested
[01:12.72]to treat paralysis in other patients.
[01:17.40]This new evidence suggests
[01:19.64]it might also aid diseases of the nervous system
[01:24.08]like spinal muscle atrophy, or SMA.
[01:30.92]SMA is a genetic disease
[01:33.84]that slowly destroys motor neurons,
[01:37.68]nerve cells in the spinal cord that control muscles.
[01:43.48]That leads muscles to waste away,
[01:46.32]especially in the legs, hips, and shoulders
[01:51.08]and sometimes those involved
[01:53.52]with breathing and swallowing.
[01:57.44]There is no cure.
[01:59.64]A gene therapy can save the lives
[02:04.00]of very young children
[02:05.84]with a severe form of the disease,
[02:08.48]and there are some medicines
[02:10.68]to slow the disease in older patients.
[02:15.20]Stimulating the spinal cord
[02:17.72]with low levels of electricity
[02:20.44]has long been used to treat chronic,
[02:23.68]or long-term, pain.
[02:26.28]Capogrosso's team also has tested it
[02:30.20]to help people paralyzed by strokes
[02:33.72]or spinal cord injury
[02:36.20]move their arms and legs with assistance.
[02:40.48]The system sends electrical signals
[02:43.20]to nerves that have stopped reacting.
[02:47.20]This has the effect of activating the muscles.
[02:51.88]Capogrosso wondered
[02:53.76]if that same technology might help patients
[02:57.32]with SMA by stimulating sensory nerves
[03:01.52]to signal damaged muscle cells
[03:04.68]causing them to move.
[03:07.80]The researchers at the University of Pittsburgh
[03:11.48]published their study in Nature Medicine.
[03:16.16]They implanted electrodes
[03:18.36]over the lower spinal cord
[03:20.80]of the three adults with SMA.
[03:24.60]Using the device did not return normal movement
[03:29.20]but with a few hours of spinal stimulation a week,
[03:33.96]all soon experienced improvements
[03:37.56]in muscle strength and function,
[03:40.72]the researchers wrote.
[03:43.84]Fifty-seven-year-old Doug McCullough
[03:46.40]took part in the study.
[03:49.28]"With a progressive disease
[03:51.28]you never get any better," he said,
[03:54.56]adding, "So having any improvement
[03:58.40]is just a really surreal
[04:00.88]and very exciting benefit."
[04:05.20]All three subjects increased
[04:07.92]how far they could walk
[04:10.08]in six minutes by the study's end.
[04:14.24]Capogrosso said they could walk farther
[04:17.40]because they got less tired
[04:20.08]and "even a person this many years
[04:23.40]into the disease can improve."
[04:27.28]Researchers found the improvements
[04:29.80]did not disappear as soon as
[04:32.40]the stimulator was turned off.
[04:34.88]But they did decrease a few months
[04:38.28]after the study ended.
[04:41.88]Neuroscientist Susan Harkema
[04:44.80]led similar studies of stimulation
[04:48.04]for spinal cord injuries
[04:50.16]while at the University of Louisville.
[04:54.16]She warned that the new study is small
[04:57.60]and did not last very long
[05:00.52]but said it was an important test of the device.
[05:06.12]She said it should be tested next
[05:09.04]with other muscle-degenerating diseases.
[05:14.52]Capogrosso said some small
[05:17.48]but longer studies are beginning.
[05:22.16]I'm Dorothy Gundy. 更多听力请访问21VOA.COM
END OF TRACK. "END OF TRACK." The two men bowed. "Whoever was that person you were talking to?" she enquired, as soon as they stood together. The took of triumph faded from her eyes, she had grown worn and weary. The roses were wilting on the walls, the lights were mostly down now. Hetty, looking in to see if anything was wanted, found herself driven away almost fiercely. I only saw Master Jervie once when he called at tea time, The year 1747 was opened by measures of restriction. The House of Lords, offended at the publication of the proceedings of the trial of Lord Lovat, summoned the parties to their bar, committed them to prison, and refused to liberate them till they had pledged themselves not to repeat the offence, and had paid very heavy fees. The consequence of this was that the transactions of the Peers were almost entirely suppressed for nearly thirty years from this time, and we draw our knowledge of them chiefly from notes taken by Horace Walpole and Lord Chancellor Hardwicke. What is still more remarkable, the reports of the House of Commons, being taken by stealth, and on the merest sufferance, are of the most meagre kind, sometimes altogether wanting, and the speeches are given uniformly under fictitious names; for to have attributed to Pitt or Pelham their[112] speeches by name would have brought down on the printers the summary vengeance of the House. Many of the members complained bitterly of this breach of the privileges of Parliament, and of "being put into print by low fellows"; but Pelham had the sense to tolerate them, saying, "Let them alone; they make better speeches for us than we can make for ourselves." Altogether, the House of Commons exhibited the most deplorable aspect that can be conceived. The Ministry had pursued Walpole's system of buying up opponents by place, or pension, or secret service money, till there was no life left in the House. Ministers passed their measures without troubling themselves to say much in their behalf; and the opposition dwindled to Sir John Hinde Cotton, now dismissed from office, and a feeble remnant of Jacobites raised but miserable resistance. In vain the Prince of Wales and the secret instigations of Bolingbroke and Doddington stimulated the spirit of discontent; both Houses had degenerated into most silent and insignificant arenas of very commonplace business. "It certainly will be. Miss Widgeon," answered Maria, with strictly "company manners." "One who has never had a brother exposed to the constant dangers of army life can hardly understand how glad we all feel to have Si snatched from the very jaws of death and brung back to us." "Just plug at 'em as you would at a crow, and then go on your way whistlin'?" persisted Harry. "Hurroo!" echoed Hennessey; "that's the ticket." "Come forward, keeper," continued the baron, "and state how these arrows came into your hands!" "Yes." HoMEJULIA京香2018下载
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